What are the recommendations for safe use of medications in patients with cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

A review by Lewis and Stine provided recommendations on the safe use of medications in patients with cirrhosis, including the following [55, 56] :

  • Lower medication doses should generally be used, particularly in patients with significant liver dysfunction

  • Proton-pump inhibitors and histamine-2 blockers should be used only for valid indications, since they may lead to serious infections in patients with cirrhosis


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