What is the frequency of hepatocellular carcinoma (HCC) in cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Hepatocellular carcinoma (HCC) ultimately arises in 10-25% of patients with cirrhosis in the United States. It typically occurs in about of 3% of patients per year, when the etiology of cirrhosis is hepatitis B, hepatitis C, or alcohol. It develops more commonly in patients with underlying hereditary hemochromatosis or alpha-1 antitrypsin deficiency. HCC is observed less commonly in primary biliary cirrhosis and is a rare complication of Wilson disease.

Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients when clinical and laboratory findings may not be sufficient. [46] This imaging modality may aid in estimating liver function reserve and its segmental distribution, particularly in those with underlying cirrhosis.

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