What is the effectiveness of lactulose in the treatment of cirrhosis?

Updated: Oct 15, 2020
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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In a study, Sharma et al concluded that the use of lactulose effectively prevents hepatic encephalopathy recurrence in cirrhosis. Patients with cirrhosis recovering from hepatic encephalopathy were randomized to receive lactulose (n = 61) or placebo (n = 64). Over a median follow-up of 14 months, 12 patients (19.6%) in the lactulose group developed hepatic encephalopathy, compared with 30 patients (46.8%) in the placebo group. [43]

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