What is the role of norfloxacin for in the treatment of cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Therapy with norfloxacin at 400 mg orally twice per day for 7 days can reduce serious bacterial infection in patients with cirrhosis who have GI bleeding. One study noted that the 37% incidence of serious bacterial infection was reduced to 10% when treatment with norfloxacin was instituted. [18] Furthermore, it can be argued that all patients with low-protein ascites should undergo prophylactic therapy (eg, with norfloxacin 400 mg daily PO) at the time of hospital admission, given the high incidence of hospital-acquired SBP. [19]


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