What are the treatment options for spontaneous bacterial peritonitis (SBP)?

Updated: Oct 15, 2020
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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The most commonly used regimen in the treatment of SBP is a 5-day course of cefotaxime at 1-2g intravenously every 8 hours. [18] Alternatives include oral ofloxacin and other IV antibiotics with activity against gram-negative enteric organisms. Many authorities advise repeat paracentesis in 48-72 hours to document a decrease in the ascites PMN count to less than 250 cells/mm3 to ensure efficacy of therapy.

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