What are the prehepatic causes of portal hypertension of cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Prehepatic causes include splenic vein thrombosis and portal vein thrombosis. These conditions commonly are associated with hypercoagulable states and with malignancy (eg, pancreatic cancer). In a retrospective study (2002-2014) of 66 patients with cirrhosis and portal vein thrombosis, Chen et al reported that warfarin anticoagulation may potentially safely and effectively resolve cases of more advanced portal vein thrombosis. [9] However, they did not observe any benefit of anticoagulation on decompensation or mortality. Levels of albumin were significant predictors of decompensated disease at 1 year. [9]


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