What causes increased resistance of portal blood flow in cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Increased resistance across the sinusoidal vascular bed of the liver is caused by fixed factors and dynamic factors. Two thirds of intrahepatic vascular resistance can be explained by fixed changes in the hepatic architecture. Such changes include the formation of regenerating nodules and, after the production of collagen by activated stellate cells, deposition of the collagen within the space of Disse.


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