What is the role of serum cytokines in the pathogenesis of cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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In a study that evaluated serum cytokine levels between healthy patients, those with stable cirrhosis, and patients with decompensated cirrhosis with and without development of acute-on-chronic liver failure (ACLF), Dirchwolf et al found the presence of distinct cytokine phenotypes was associated with cirrhosis severity. [7] Relative to the healthy patients, those with cirrhosis had elevated levels of proinflammatory cytokines (interleukin [IL]-6, -7, -8, -10, and -12, and tumor necrosis factor-alpha [TNF-α]) and chemoattractant elements. Leukocyte count was positively correlated with disease severity across the scoring systems used, levels of IL-6 and IL-8 had positive correlation with Model for End-Stage Liver Disease (MELD) score, and IL-6 alone had a positive correlation with chronic liver failure-sequential organ failure assessment (Clif-SOFA) score at day 7 (but a negative correlation with IL-2 at admission). [7]

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