What are the causes of cryptogenic cirrhosis?

Updated: Jul 30, 2018
  • Author: David C Wolf, MD, FACP, FACG, AGAF, FAASLD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Many cases of cryptogenic cirrhosis appear to have resulted from nonalcoholic fatty liver disease (NAFLD). When cases of cryptogenic cirrhosis are reviewed, many patients have 1 or more of the classic risk factors for NAFLD: obesity, diabetes, and hypertriglyceridemia. [3] It is postulated that steatosis may regress in some patients as hepatic fibrosis progresses, making the histologic diagnosis of NAFLD difficult. Flavinoids have been reported to have positive effects on key pathophysiologic pathways in NAFLD (eg, lipid metabolism, insulin resistance, inflammation, oxidative stress) and may hold future potential for inclusion in NAFLD treatment. [4]


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