Which medications have been FDA approved to treat opioid-induced constipation (OIC)?

Updated: Jul 05, 2019
  • Author: Marc D Basson, MD, PhD, MBA, FACS; Chief Editor: BS Anand, MD  more...
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Answer

Medications to treat OIC and provide analgesia have been approved by the FDA. Lubiprostone (Amitiza) was approved in 2013 and is the first oral treatment for OIC in adults with chronic noncancer pain. [47, 48] The drug is a specific activator of CIC-2 chloride channels in the intestinal epithelium and bypasses the antisecretory action of opiates by activation of apical CIC-2 channels. Approval was based on results from 12-week phase 3 studies in patients taking opioids, including morphine, oxycodone, and fentanyl, for chronic noncancer pain and from a long-term open-label safety study. [47]


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