How is linaclotide used in the treatment of constipation and what was the FDA approval based on?

Updated: Jul 05, 2019
  • Author: Marc D Basson, MD, PhD, MBA, FACS; Chief Editor: BS Anand, MD  more...
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Answer

Linaclotide was approved by the US Food and Drug Administration (FDA) in August 2012 to treat chronic idiopathic constipation and for IBS with constipation (IBS-C) in adults. Approval was based on randomized controlled trials that showed significant improvement for each indication compared with placebo. [30, 31, 32]


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