How effective is lubiprostone in the treatment of constipation?

Updated: Mar 30, 2020
  • Author: Marc D Basson, MD, PhD, MBA, FACS; Chief Editor: BS Anand, MD  more...
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A 2013 study illustrated the long-term efficacy of lubiprostone for opioid-induced constipation. [31] In a 9-month open-label extension study in 439 patients, lubiprostone treatment (24 μg twice daily) resulted in statistically significant improvements in constipation from baseline determined by monthly assessments. Patients also reported improvements in the average degree of straining, stool consistency, constipation severity, abnormal bloating and discomfort, and bowel habit irregularity (P< .001 at all treatment months). Reliance on rescue medication significantly dropped over the course of the study, from 33% at month 1 to 18.6% at month 9. Treatment-related adverse events were reported by 24.6% of patients, the most common being nausea, diarrhea, and flatulence. [31]

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