Which disorders and diseases are associated with constipation?

Updated: Mar 30, 2020
  • Author: Marc D Basson, MD, PhD, MBA, FACS; Chief Editor: BS Anand, MD  more...
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Neurologic and endocrine disorders also can cause constipation. Most notably, diabetes may be associated with chronic dysmotility. Patients with hypothyroidism may exhibit decreased motility and slow transit times. [18] Patients with panhypopituitarism, pheochromocytoma, or multiple endocrine neoplasia 2B are also at risk for constipation. When no other cause can be determined, a careful endocrine review is particularly important for patients with a recent onset of constipation and for patients whose constipation is refractory to conservative treatment.

Similarly, central nervous system (CNS) diseases, such as Parkinson disease, multiple sclerosis, stroke, CNS syphilis, and spinal injury or tumors, may cause constipation and should be considered in the patient’s history and evaluation.

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