What is the role of liver biopsy in the diagnosis of Budd-Chiari syndrome?

Updated: Oct 10, 2018
  • Author: Praveen K Roy, MD, AGAF; Chief Editor: BS Anand, MD  more...
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Percutaneous liver biopsy can be of prognostic assistance, particularly if liver transplantation is being considered, to establish the degree of hepatocellular damage and the presence and degree of fibrosis. [28]

Pathologic findings in liver biopsy are (1) high-grade venous congestion and centrilobular liver cell atrophy, and, possibly, (2) thrombi within the terminal hepatic venules. The extent of fibrosis can be determined based on biopsy findings. The most severe findings can include fulminant hepatic failure with massive centrilobular necrosis.

Studies have indicated, however, that early pathology related to Budd-Chiari syndrome does not have a significant impact on survival. [29]

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