Which factors are associated with a good prognosis of Budd-Chiari syndrome?

Updated: Oct 10, 2018
  • Author: Praveen K Roy, MD, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

The natural history of Budd-Chiari syndrome is not well known. The following factors, however, have been associated with a good prognosis:

  • Younger age at diagnosis

  • Low Child-Pugh score

  • Absence of ascites or easily controlled ascites

  • Low serum creatinine level

In a systematic review of 79 studies, investigators found that although univariate analysis indicated bilirubin and creatinine levels as well as ascites might be significant prognostic factors, multivariate analyses did not always reveal achievement of statistical significance. [15]

The following formula has been proposed to calculate the prognostic index for Budd-Chiari syndrome; a score of less than 5.4 is associated with a good prognosis:

  • Prognostic index = (ascites score x 0.75) + (Pugh score x 0.28) + (age x 0.037) + (creatinine level x 0.0036)


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