What causes Budd-Chiari syndrome?

Updated: Oct 10, 2018
  • Author: Praveen K Roy, MD, AGAF; Chief Editor: BS Anand, MD  more...
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Most patients with Budd-Chiari syndrome have an underlying thrombotic diathesis, although in approximately one third of patients, the condition is idiopathic. Thus, it may be a primary venous problem or an intra-/extrahepatic space-occupying lesion compressing/invading the venous outflow. [49] Causes of Budd-Chiari syndrome include the following:

  • Hematologic disorders

  • Inherited or acquired thrombotic diathesis [49]

  • Pregnancy and postpartum [11]

  • Oral contraceptives [49]

  • Chronic infections

  • Chronic inflammatory diseases

  • Tumors

  • Congenital membranous obstruction

  • Hepatic venous stenosis

  • Hypoplasia of the suprahepatic veins

  • Postsurgical obstruction

  • Posttraumatic obstruction

  • Malnutrition [49]

  • Total parenteral nutrition (TPN): Budd-Chiari syndrome has been reported as a complication of TPN via an IVC catheter in a neonate

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