When should Wilson disease be suspected?

Updated: Feb 14, 2019
  • Author: Richard K Gilroy, MBBS, FRACP; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Wilson disease has a range of clinical manifestations, from an asymptomatic state to fulminant hepatic failure, chronic liver& disease with or without cirrhosis, neurologic, and psychiatric manifestations. [2]

Consider hepatic Wilson disease in the differential diagnosis of any unexplained chronic liver disease, especially in individuals younger than 40 years. [12] The condition may also manifest as acute hepatitis. Hepatic dysfunction is the presenting feature in more than half of patients. The three major patterns of hepatic involvement are as follows: (1) chronic active hepatitis, (2) cirrhosis, and (3) fulminant hepatic failure. The most common initial presentation is cirrhosis.


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