What are the treatment options for Wilson disease?

Updated: Feb 14, 2019
  • Author: Richard K Gilroy, MBBS, FRACP; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Features of treatment of Wilson disease are as follows:

  • The mainstay of therapy is lifelong use of chelating agents (eg, penicillamine, trientine)

  • Symptoms, particularly neurologic ones, may worsen with initiation of chelation

  • Surgical decompression or transjugular intrahepatic shunting (TIPS) is reserved for recurrent or uncontrolled variceal bleeding unresponsive to standard conservative measures

  • Orthotopic liver transplantation is curative


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