What are musculoskeletal manifestations of Wilson disease?

Updated: Feb 14, 2019
  • Author: Richard K Gilroy, MBBS, FRACP; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Musculoskeletal manifestations

  • The arthropathy of Wilson disease is a degenerative process that resembles premature osteoarthritis

  • Symptomatic joint disease usually arises late in the course of the disease, frequently after age 20 years

  • The arthropathy generally involves the spine and large appendicular joints (eg, knees, wrists, hips)

  • Osteochondritis dissecans, chondromalacia patellae, and chondrocalcinosis have also been described

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