What is the prevalence of depression in patients with Parkinson disease (PD)?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Depression is one of the most common nonmotor symptoms of Parkinson disease, occurring in approximately 35% of patients. [106, 107] This condition is more common in patients with Parkinson disease than in the general elderly population and in those with chronic conditions such as osteoarthritis. Depression in Parkinson disease has a profound impact on quality of life and is associated with reduced function, cognitive impairment, and increased caregiver stress.

A systematic review of prevalence studies of depression in Parkinson disease found that 17% of patients present with major depression, 22% with minor depression, and 13% with dysthymia [108] Moreover, multiple studies have found that a history of depression is a risk factor for the subsequent development of Parkinson disease. [109]

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