Is methylphenidate effective in improving gait disorders in patients with advanced Parkinson disease (PD)?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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A randomized trial by Moreau et al assessed the effectiveness of the drug methylphenidate in improving gait disorders and freezing of gait in patients with advanced Parkinson disease without dementia who also received subthalamic nucleus stimulation (STN). Eighty-one patients from 13 movement disorders departments in France were randomly assigned to methylphenidate or placebo for 90 days. Compared with patients in the placebo group, patients in the methylphenidate group used fewer steps at 90 days. These results suggest methylphenidate may improve gait hypokinesia and freezing although further study is needed to determine long-term risks. [88]

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