What are the potential neuroprotective effects of dopamine agonists in Parkinson disease (PD)?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Dopamine agonists have been used to provide symptomatic relief in early Parkinson disease. In vivo experiments have demonstrated that the ergot and nonergot dopamine agonists protect cultured cells from death due to oxidative damage. Clinical data in patients with early Parkinson disease provide neuroimaging results that suggest a possible neuroprotective effect. [73, 75] Various studies have been conducted with ropinirole and pramipexole; however, definitive neuroprotection cannot be confirmed on the basis of these studies. [76, 77]


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