When should dopaminergic therapy be increased to eliminate off-time in patients with Parkinson disease (PD)?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Unless limited by the emergence of peak-dose symptoms such as dyskinesia or hallucinations, dopaminergic therapy should be increased until off-time is eliminated. Once-daily formulations of the dopamine agonists ropinirole and pramipexole are now available. These medications appear to provide efficacy and safety similar to the IR formulations that are administered 3 times daily. [62]


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