Does amantadine increase or decrease impulse control disorders in patients with Parkinson disease (PD)?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

In a small, double-blind crossover study, amantadine was found to ameliorate pathologic gambling associated with Parkinson disease. [53] However, in a large cross-sectional study, amantadine was associated with a higher prevalence of impulse control disorders, including gambling. [54] Thus, further research is needed to understand the role of amantadine as a treatment or cause of impulse control disorders in patients with Parkinson disease.


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