What are the available preparations of levodopa/carbidopa?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Currently available levodopa preparations in the United States include levodopa/carbidopa immediate-release (IR) tablets (Sinemet), levodopa/carbidopa controlled-release (CR) tablets (Sinemet CR), and levodopa/carbidopa orally disintegrating tablets (Parcopa). The orally disintegrating tablet is bioequivalent to oral levodopa/carbidopa IR, but it dissolves on the tongue without the need to swallow it with water. The orally disintegrating tablet is not absorbed in the mouth but travels in the saliva to absorption sites in the proximal small bowel (where other levodopa preparations are also absorbed).


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