How is the clinical diagnosis of Parkinson disease (PD) confirmed?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

A substantial and sustained response to dopamine medications (dopamine agonists or levodopa) helps confirm a diagnosis of Parkinson disease. It is unclear whether acute levodopa or apomorphine challenge has any advantage over clinical diagnostic criteria. [22] Over time, diagnostic accuracy improves as the progression of signs and symptoms and response to medications unfolds.


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