How is Parkinson disease (PD) severity assessed and staged?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Investigators have proposed a staging system to improve the assessment of overall Parkinson disease severity. In an observational, cross-sectional study of 933 patients with Parkinson disease, Ray Chaudhuri and colleagues found a wide discrepancy between the severity of nonmotor symptoms as measured by the NonMotor Symptoms Scale (NMSS) and motor symptoms as measured by the Hoehn and Yahr scale. [30, 31] The investigators proposed a staging system for nonmotor symptom burden based on NMSS scores, which was correlated with measures of disability and quality of life. The staging system rates nonmotor symptom burden (NMSB) on a scale of 0 (no NMSB) to 4 (very severe NMSB). [30, 31]

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