What are the initial clinical symptoms of Parkinson disease (PD)?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Initial clinical symptoms of Parkinson disease include the following:

  • Tremor

  • Subtle decrease in dexterity

  • Decreased arm swing on the first-involved side

  • Soft voice

  • Decreased facial expression

  • Sleep disturbances

  • Rapid eye movement (REM) behavior disorder (RBD; a loss of normal atonia during REM sleep)

  • Decreased sense of smell

  • Symptoms of autonomic dysfunction (eg, constipation, sweating abnormalities, sexual dysfunction, seborrheic dermatitis)

  • A general feeling of weakness, malaise, or lassitude

  • Depression or anhedonia

  • Slowness in thinking

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