Which medications in the drug class Adenosine Antagonists are used in the treatment of Parkinson Disease?

Updated: Aug 29, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Adenosine Antagonists

Option for adjunctive use with levodopa/carbidopa to reduce Parkinson disease OFF episodes.

Istradefylline (Nourianz)

Selective adenosine A2A receptor antagonist. Precise mechanism by which it reduces OFF episodes is unknown. Istradefylline is indicated as adjunctive treatment to levodopa/carbidopa in adults with PD experiencing OFF episodes.

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