Which medications in the drug class Selective Serotonin Inverse Agonists (SSIA) are used in the treatment of Parkinson Disease?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Selective Serotonin Inverse Agonists (SSIA)

SSIAs preferentially target 5-HT2A receptors, but does not affect activity of dopamine and other receptors commonly targeted by antipsychotics.

Pimavanserin (Nuplazid)

Pimavanserin is an SSIA which preferentially targets 5-HT2A receptors and avoids activity at dopamine and other receptors commonly targeted by antipsychotics. It is indicated for hallucinations and delusions associated with PD.


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