How is levodopa-induced nausea avoided in patients with Parkinson disease (PD)?

Updated: Jan 24, 2019
  • Author: Robert A Hauser, MD, MBA; Chief Editor: Selim R Benbadis, MD  more...
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Answer

Even if there is some reduction in clinical benefit when levodopa is taken with meals, this can be mitigated by increasing the levodopa dose, if necessary. In patients with early disease, the primary concern regarding levodopa is typically nausea, which is less likely to occur if they take their levodopa dose at the completion of meals. Therefore, in early Parkinson disease, it is common to instruct patients to take their levodopa after meals to reduce the likelihood of nausea as the dose is titrated to clinical effect.


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