How are types IIA and IIB hyperlipoproteinemia (HLP) treated?

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

When beginning medications, the assumption is that nonpharmacologic measures (as described above) did not achieve an LDL-C level of 160 mg/dL or lower after 6-12 months. Pharmacotherapy should be considered in children older than 10 years with type IIA or type IIB HLP if the following are noted.

An LDL-C level of 160-189 mg/dL and a family history of premature cardiovascular disease or two of the following risk factors:

  • Smoking.

  • Hypertension.

  • HDL-C level of less than 35 mg/dL.

  • Severe obesity (>30% more than ideal body weight).

  • Diabetes mellitus.

  • Physical inactivity.

  • Male sex.

  • Renal disease.

Also, an LDL-C level of 190 mg/dL or higher, regardless of other risk factor status.


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