What is the role of pediatric lipid testing in the screening for adult cardiovascular risk?

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Non-HDL cholesterol (ie, the TC minus the HDL-C) has been shown to be an excellent measure of risk for cardiovascular disease in adults. Both of the major non-HDL lipoproteins (LDL and very low-density lipoprotein [VLDL]) are the apoprotein-B-containing lipoproteins.

A systematic review of the evidence on benefits and harms of screening adolescents and children for heterozygous familial hypercholesterolemia (FH) indicates that screening in children can detect FH and that lipid-lowering treatment in childhood can lower lipid concentrations in the short term, with little evidence of harm. [12] However, the investigators found no evidence for the effect of childhood screening for FH on lipid concentrations or cardiovascular outcomes in adulthood, or on the long-term benefits or harms of starting lipid-lowering treatment in childhood. [12]


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