What are the AACE/ACE guidelines for interpreting pediatric lipid profiles?

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

The 2017 American Association for Clinical Endocrinology (AACE) and American College of Endocrinology (ACE) guidelines indicate the following points should be considered when interpreting lipid profiles in children and adolescents [3] :

  • Lipid levels fluctuate during childhood and adolescence: Although plasma cholesterol levels normally peak before puberty (age 9-11 y) in boys, they often decline during puberty, along with high-density lipoprotein cholesterol (HDL-C) values.
  • Low HDL-C may not have the same implications in children as it does in adults: Over 50% of children with low HDL-C levels have normal HDL-C levels as adults. Furthermore, low HDL-C values do not constitute a hallmark of the insulin resistance syndrome in children; in this population, obesity and hypertriglyceridemia are the best predictors of this condition.
  • Lipid levels vary by sex: Throughout childhood and adolescence, plasma cholesterol levels tend to be higher in girls than in boys.

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