What are the AACE/ACE guidelines for interpreting pediatric lipid profiles?

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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The 2017 American Association for Clinical Endocrinology (AACE) and American College of Endocrinology (ACE) guidelines indicate the following points should be considered when interpreting lipid profiles in children and adolescents [3] :

  • Lipid levels fluctuate during childhood and adolescence: Although plasma cholesterol levels normally peak before puberty (age 9-11 y) in boys, they often decline during puberty, along with high-density lipoprotein cholesterol (HDL-C) values.
  • Low HDL-C may not have the same implications in children as it does in adults: Over 50% of children with low HDL-C levels have normal HDL-C levels as adults. Furthermore, low HDL-C values do not constitute a hallmark of the insulin resistance syndrome in children; in this population, obesity and hypertriglyceridemia are the best predictors of this condition.
  • Lipid levels vary by sex: Throughout childhood and adolescence, plasma cholesterol levels tend to be higher in girls than in boys.

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