What is the Frederickson Classification of dyslipidemias?

Updated: Jun 27, 2019
  • Author: Henry J Rohrs, III, MD; Chief Editor: Stuart Berger, MD  more...
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Answer

Table 2, below, depicts the Frederickson classification scheme, used to distinguish dyslipidemias.

Table 2. Frederickson Classification of Dyslipidemias (Open Table in a new window)

Phenotype

Elevated Particles

Major Lipid Increased

Frequency

I

Chylomicron

TG

Very rare

IIA

LDL

LDL-C

Common

IIB

LDL and VLDL

LDL-C, TG

Common

III

IDL and remnants

TC, TG

Rare

IV

VLDL

TG

Common

V

Chylomicron and VLDL

TG

Uncommon

IDL = intermediate-density lipoprotein; LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; TG = triglycerides; VLDL = very low-density lipoprotein.

 

The most common dyslipidemias are types IIA, IIB, and IV. Type I and type III hyperlipoproteinemia (HLP) are extremely rare in pediatric patients, and type V is uncommon.


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