What are the benefits of polyglytone 621 (Caprosyn) sutures compare to chromic gut sutures?

Updated: Mar 05, 2020
  • Author: Desiree Ratner, MD; Chief Editor: Dirk M Elston, MD  more...
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When Pineros-Fernandez et al compared the biomechanical performance of polyglytone 621 (Caprosyn) suture with that of chromic gut suture, both suture types provided comparable resistance to wound disruption. [27] The biomechanical performance studies included quantitative measurements of wound security, strength loss, mass loss, potentiation of infection, tissue drag, knot security, and knot rundown, as well as suture stiffness.

Before implantation, suture loops of Caprosyn had significantly greater mean breaking strength than suture loops of chromic gut did [27] ; 3 weeks after implantation of these absorbable suture loops, the sutures had no appreciable strength. The rate loss of suture mass of these two sutures was similar.

As expected, chromic gut sutures potentiated significantly more infection than Caprosyn sutures did. [27] However, the handling properties of Caprosyn sutures were far superior to those of chromic gut sutures, and the smooth surface of the Caprosyn sutures encountered lower drag forces than the chromic gut sutures did. Furthermore, it was much easier to reposition the Caprosyn knotted sutures than the knotted chromic gut sutures. In the case of chromic gut sutures, it was not possible to reposition a two-throw granny knot.

These biomechanical performance studies demonstrated the superior performance of the synthetic Caprosyn sutures compared with chromic gut sutures and provided compelling evidence of why Caprosyn sutures are an excellent alternative to chromic gut sutures.

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