What patient characteristics are associated with Peutz-Jeghers syndrome (PJS)?

Updated: Oct 11, 2018
  • Author: Buu Anh T To, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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The following patient characteristics may be noted in the Peutz-Jeghers syndrome [19, 20] :

  • Family history of Peutz-Jeghers syndrome
  • Repeated bouts of abdominal pain in patients younger than 25 years
  • Unexplained intestinal bleeding in a young patient
  • Prolapse of tissue from the rectum
  • Menstrual irregularities in females (due to hyperestrogenism from sex cord tumors with annular tubules)
  • Gynecomastia in males (possible due to the production of estrogens from Sertoli cell testicular tumors) [2, 77]
  • Precocious puberty
  • Gastrointestinal intussusception with bowel obstruction
  • Mucocutaneous pigmentation, which may have faded
  • Melena or rectal bleeding
  • Hematemesis
  • Weakness due to anemia

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