What are GI complications of Peutz-Jeghers syndrome (PJS)?

Updated: Oct 11, 2018
  • Author: Buu Anh T To, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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In a series of 222 patients with Peutz-Jeghers syndrome (PJS), Utsunomiya et al noted the following distribution of presenting gastrointestinal symptoms [16] :

  • Obstruction: 42.8% of patients
  • Abdominal pain caused by infarction: 23% of patients
  • Rectal bleeding caused by ulceration: 13.5% of patients
  • Extrusion of polyp: 7% of patients

Gastric outlet obstruction can be an early presenting complaint in Peutz-Jeghers syndrome, including in the neonatal period. [58] Recurrent abdominal pain is often reported with increased frequency and intensity, as small intestinal polyp growth evolves into subtotal obstruction. Gastrointestinal hemorrhage may not be apparent and may present as iron deficiency anemia.

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