What drug treatments are available for symptomatic treatment of peptic ulcer disease (PUD)?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Antacids or a gastrointestinal (GI) cocktail (typically an antacid with an anesthetic such as viscous lidocaine and/or an antispasmodic) may be used as symptomatic therapy; however, relief of symptoms with a GI cocktail is not a diagnostic indicator.

Empiric treatment of H pylori is not recommended. Therapy is indicated only after confirmation of infection. These tests are not performed in the ED. Empiric trial of acid suppression in patients younger than 55 years without alarm features may be initiated with a proton pump inhibitor (PPI) for 4-8 weeks. Appropriate follow-up is required to assess response in 2-4 weeks. [64]

Anticholinergic agents are contraindicated.

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