Which clinical findings suggest uncomplicated peptic ulcer disease (PUD)?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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In uncomplicated peptic ulcer disease, the clinical findings are few and nonspecific and include the following:

  • Epigastric tenderness (usually mild)

  • Right upper quadrant tenderness may suggest a biliary etiology or, less frequently, peptic ulcer disease

  • Guaiac-positive stool resulting from occult blood loss

  • Melena resulting from acute or subacute gastrointestinal bleeding

  • Succussion splash resulting from partial or complete gastric outlet obstruction

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