What are the signs and symptoms of peptic ulcer disease (PUD)?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Other possible manifestations include the following:

  • Dyspepsia, including belching, bloating, distention, and fatty food intolerance

  • Heartburn

  • Chest discomfort

  • Hematemesis or melena resulting from gastrointestinal bleeding. Melena may be intermittent over several days or multiple episodes in a single day.

  • Rarely, a briskly bleeding ulcer can present as hematochezia.

  • Symptoms consistent with anemia (eg, fatigue, dyspnea) may be present

  • Sudden onset of symptoms may indicate perforation.

  • NSAID-induced gastritis or ulcers may be silent, especially in elderly patients.

  • Only 20-25% of patients with symptoms suggestive of peptic ulceration are found on investigation to have a peptic ulcer.

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