Which factors increase the mortality risk associated with emergency surgery for peptic ulcer perforation?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Emergency operations for peptic ulcer perforation carry a mortality risk of 6-30%. [29, 30] Factors associated with higher mortality in this setting include the following:

  • Shock at the time of admission

  • Renal insufficiency

  • Delaying the initiation of surgery for more than 12 hours after presentation

  • Concurrent medical illness (eg, cardiovascular disease, diabetes mellitus)

  • Age older than 70 years

  • Cirrhosis

  • Immunocompromised state

  • Location of ulcer (mortality associated with perforated gastric ulcer is twice that associated with perforated duodenal ulcer)

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