What is the international prevalence of peptic ulcer disease?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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The global incidence and prevalence of peptic ulcer disease, along with the associated rates of hospitalizations and mortality, have been in decline over the past couple of decades, attributed in part to the complex changes in the risk factors for peptic ulcer disease, including reductions in the prevalence of H pylori infection, the widespread use of antisecretory agents and nonsteroidal anti-inflammatory drugs (NSAIDs), and an aging population. [19]

The frequency of peptic ulcer disease in other countries is variable and is determined primarily by association with the major causes of peptic ulcer disease: H pylori and NSAIDs. [23] A 2018 systematic MEDLINE and PubMed review found Spain had the highest annual incidence of all peptic ulcer disease (141.8/100,000 persons), whereas the United Kingdom had the lowest (23.9/100,000 persons). [24] When perforated peptic ulcer disease was assessed, South Korea had the highest annual incidence (4.4/100,000 persons) and the United Kingdom, again, had the lowest (2.2/100,000 persons). [24]

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