Does cold climate increase the risk of developing peptic ulcer disease (PUD)?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Seasonal changes and climate extremes may also affect gastric mucosa and cause damage to the gastric mucosa and its barrier function. [18] In extreme cold climate, Yuan et al noted significantly lower expression of heat shock protein 70 (HSP70) as well as decreased mucosal thickness in the gastric antrum of patients with peptic ulcer disease who were at high risk of bleeding compared to those at low risk of bleeding.

Moreover, compared to extreme hot climate, extreme cold climate was associated with significantly lower levels of occludin, HSP70, nitric oxide synthase (NOS), and epidermal growth factor receptor (EGFR), but no statistically significant differences in these protein expression levels were found between patients at high and low risk of bleeding. [18] The investigators also did not note any significant differences found in the rates of H pylori infection and pH levels of gastric juices between patients at high bleeding risk and those at low bleeding risk. [18]

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