Do corticosteroids increase the risk of peptic ulcer disease (PUD)?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Answer

Corticosteroids alone do not increase the risk for peptic ulcer disease; however, they can potentiate ulcer risk in patients who use NSAIDs concurrently.

The risk of upper GI tract bleeding may be increased in users of the diuretic spironolactone [12] or serotonin reuptake inhibitors with moderate to high affinity for serotonin transporter. [13]


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