Which factors increase the risk for peptic ulcer disease (PUD) in patients taking low-dose aspirin?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Answer

A UK retrospective study of patients newly initiated on low-dose aspirin for secondary prevention of cardiovascular events identified risk factors for uncomplicated peptic ulcer disease in these patients that included the following [8] :

  • Previous history of peptic ulcer disease

  • Current use of NSAIDs, oral steroid agents, or acid suppressive agents

  • Tobacco use

  • Stress

  • Depression

  • Anemia

  • Social deprivation (comprises four census variables used in the Townsend deprivation index [9] : households that lack a car, are overcrowded, not owner-occupied, and have unemployed persons)


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