How is peptic ulcer disease (PUD) treated?

Updated: Apr 26, 2021
  • Author: BS Anand, MD; Chief Editor: Philip O Katz, MD, FACP, FACG  more...
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Most patients with peptic ulcer disease are treated successfully with cure of H pylori infection and/or avoidance of nonsteroidal anti-inflammatory drugs (NSAIDs), along with the appropriate use of antisecretory therapy. In the United States, the recommended primary therapy for H pylori infection is proton pump inhibitor (PPI)–based triple therapy. [1] These regimens result in a cure of infection and ulcer healing in approximately 85-90% of cases. [2] Ulcers can recur in the absence of successful H pylori eradication. (See Treatment.)

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