What are the benefits of the exogenous pancreatic enzymes for treatment of chronic pancreatitis?

Updated: Jul 15, 2019
  • Author: Jason L Huffman, MD; Chief Editor: BS Anand, MD  more...
  • Print
Answer

Clinical trials investigating the benefits of this approach have provided mixed results. While four trials using enteric-coated enzyme preparations demonstrated no effect, these studies may have been flawed if the coating failed to release the enzymes into the feedback-sensitive portion of the duodenum. Two studies using non–enteric-coated tablets have demonstrated a reduction in pain compared with placebo. Female patients and those with idiopathic chronic pancreatitis appear to respond best.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!