Which medications in the drug class Vaccines are used in the treatment of H1N1 Influenza (Swine Flu)?

Updated: Apr 09, 2019
  • Author: Michael Stuart Bronze, MD; Chief Editor: Russell W Steele, MD  more...
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Answer

Vaccines

Influenza vaccine is administered each year before flu season. The vaccines may contain either 3 virus strains (2 influenza A and 1 influenza B) or 4 virus strains (2 influenza A strains and 2 influenza B strains), which antigenically represent the influenza strains likely to circulate the next flu season, in the formulation each year. The US Food and Drug Administration (FDA) makes the final decision about vaccine strains for influenza vaccines to be sold in the United States, based on year-round surveillance conducted by the US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO).

Influenza virus vaccine trivalent (Fluzone, Agriflu, Flucelvax, Fluarix, Fluvirin, Fluzone High-Dose, Fluzone Intradermal)

Influenza vaccine is indicated for active immunization to prevent infection from influenza A and B viruses. The vaccine induces antibodies specific to virus strains contained in the vaccine. The FDA determines influenza vaccine contents annually. Carefully check the indications and age ranges for various brands of influenza vaccine. For example, Fluzone is approved for children as young as 6 months, whereas Fluvirin is approved for children aged 4 years or older. Fluzone High-Dose is specifically formulated to provide a higher antigen content to evoke a stronger immune response in patients aged ≥65 years.

Influenza virus vaccine quadrivalent (Afluria Quadrivalent, Fluarix Quadrivalent, Flucelvax Quadrivalent)

Quadrivalent vaccines contain 2 strains of influenza A and 2 strains of influenza B. The vaccine induces antibodies specific to virus strains contained in the vaccine. Each year, the US Public Health Service determines which viral strains will be included in the seasonal influenza vaccine that will antigenically represent the viral strains most likely to circulate in the next flu season. It is administered as an IM injection and approved for adults and children 3 years or older.

Influenza virus vaccine trivalent, recombinant (Flublok)

This vaccine is made from recombinant hemagglutinin proteins that are not derived from egg or chick embryo. Influenza vaccine is indicated for active immunization to prevent infection from influenza A and B viruses. The vaccine induces antibodies specific to virus strains contained in the vaccine. The US Public Health Service determines influenza vaccine contents annually. Typically, 3 live attenuated virus strains, which antigenically represent the influenza strains likely to circulate the next flu season, are included in the formulation each year. It is administered as an IM injection and approved for adults aged 18-49 years.

Influenza virus vaccine quadrivalent, recombinant (Flublok Quadrivalent)

This vaccine is made from recombinant hemagglutinin proteins that are not derived from egg or chick embryo. Contains 4 viral strains (2 influenza A strains and 2 influenza B strains), which antigenically represent the influenza strains likely to circulate the next flu season.

Influenza virus vaccine trivalent, adjuvanted (Fluad)

Contains 3 viral strains (2 influenza A and 1 influenza B) which antigenically represent the influenza strains likely to circulate the next flu season, in the formulation each year.

Influenza virus vaccine quadrivalent, intranasal (FluMist Quadrivalent)

Discontinued for 2016/2017 Northern Hemisphere season because of low efficacy during several preceding years. The intranasal influenza vaccine is indicated for active immunization to prevent influenza A and B viruses in healthy children, adolescents, and adults. Quadrivalent vaccines contain 2 strains of influenza A and 2 strains of influenza B. The vaccine induces antibodies specific to virus strains contained in the vaccine. Each year, the US Public Health Service determines which viral strains will be included in the seasonal influenza vaccine that will antigenically represent the viral strains most likely to circulate in the next flu season.


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