What is the role of recombinant trivalent and quadrivalent vaccines in the treatment of H1N1 influenza (swine flu)?

Updated: Apr 09, 2019
  • Author: Michael Stuart Bronze, MD; Chief Editor: Russell W Steele, MD  more...
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Recombinant trivalent and quadrivalent vaccines (Flublok) are also available for adults aged 18-49 years. These are made from hemagglutinin proteins that are not derived from egg or chick embryo.

ACIP recommends against using intranasal flu vaccine during the 2016-2017 influenza season

In June 2016, CDC’s Advisory Committee on Immunization Practices (ACIP) voted that LAIV (FluMist Quadrivalent) should not be used during the 2016-2017 flu season. This ACIP vote was based on data showing poor or relatively lower effectiveness of LAIV from 2013-2016. In late May 2016, preliminary data on the effectiveness of LAIV among children aged 2-17 years during the 2015-2016 season became available from the US Influenza Vaccine Effectiveness (VE) Network. The LAIV VE among study participants in that age group against any flu virus was 3% (95% CI, -49% to 37%). In comparison, IIV (flu shots) had a VE estimate of 63% (95% CI, 52-72%) against any flu virus among children aged 2-17 years. [40]

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